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10.1016/j.celrep.2016.02.036 http://scihub22266oqcxt.onion/10.1016/j.celrep.2016.02.036 C4807727!4807727!26947063     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26947063.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Rep 2016 ; 14 (10): 2301-12 Nephropedia Template TP {{tp|p=26947063|t=2016. YAP Induces Human Naive Pluripotency |pdf=|usr=}}{{26947063}} gab.com Text YAP Induces Human Naive Pluripotency JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26947063 #FOAvip The human naive pluripotent stem cell (PSC) state, corresponding to a pre-implantation stage of development, has been difficult to capture and sustain in vitro. We report that the Hippo pathway effector YAP is nuclearly localized in the inner cell mass of human blastocysts. Overexpression of YAP in human embryonic stem cells (ESCs) and induced PSCs (iPSCs) promotes the generation of naive PSCs. Lysophosphatidic acid (LPA) can partially substitute for YAP to generate transgene-free human naive PSCs. YAP- or LPA-induced naive PSCs have a rapid clonal growth rate, a normal karyotype, the ability to form teratomas, transcriptional similarities to human pre-implantation embryos, reduced heterochromatin levels, and other hallmarks of the naive state. YAP/LPA act in part by suppressing differentiation-inducing effects of GSK3 inhibition. CRISPR/Cas9-generated YAP?/? cells have an impaired ability to form colonies in naive but not primed conditions. These results uncover an unexpected role for YAP in the human naive state, with implications for early human embryology. Twit Text FOAVip YAP Induces Human Naive Pluripotency ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26947063 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26947063 #FOAvip English Wikipedia <ref>{{Cite pmid|26947063}}</ref> YAP Induces Human Naive Pluripotency #MMPMID26947063 Qin H; Hejna M; Liu Y; Percharde M; Wossidlo M; Blouin L; Durruthy-Durruthy J; Wong P; Qi Z; Yu J; Qi LS; Sebastiano V; Song JS; Ramalho-Santos M Cell Rep 2016[Mar]; 14 (10): 2301-12 PMID26947063show ga The human naive pluripotent stem cell (PSC) state, corresponding to a pre-implantation stage of development, has been difficult to capture and sustain in vitro. We report that the Hippo pathway effector YAP is nuclearly localized in the inner cell mass of human blastocysts. Overexpression of YAP in human embryonic stem cells (ESCs) and induced PSCs (iPSCs) promotes the generation of naive PSCs. Lysophosphatidic acid (LPA) can partially substitute for YAP to generate transgene-free human naive PSCs. YAP- or LPA-induced naive PSCs have a rapid clonal growth rate, a normal karyotype, the ability to form teratomas, transcriptional similarities to human pre-implantation embryos, reduced heterochromatin levels, and other hallmarks of the naive state. YAP/LPA act in part by suppressing differentiation-inducing effects of GSK3 inhibition. CRISPR/Cas9-generated YAP?/? cells have an impaired ability to form colonies in naive but not primed conditions. These results uncover an unexpected role for YAP in the human naive state, with implications for early human embryology. äYAP Induces Human Naive Pluripotency (epmc).pdf DeepDyve Pubget Overpricing