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10.1016/j.addr.2017.01.005 http://scihub22266oqcxt.onion/10.1016/j.addr.2017.01.005 C5519456!5519456 !28111348     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28111348 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Adv+Drug+Deliv+Rev 2017 ; 116 (ä): 73-91 Nephropedia Template TP {{tp|p=28111348 |t=2017. Xenobiotic transporters and kidney injury |pdf=|usr=}}{{28111348 }} gab.com Text Xenobiotic transporters and kidney injury JO: Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=28111348 #FOAvip Renal proximal tubules are targets for toxicity due in part to the expression of transporters that mediate the secretion and reabsorption of xenobiotics. Alterations in transporter expression and/or function can enhance the accumulation of toxicants and sensitize the kidneys to injury. This can be observed when xenobiotic uptake by carrier proteins is increased or efflux of toxicants and their metabolites is reduced. Nephrotoxic chemicals include environmental contaminants (halogenated hydrocarbon solvents, the herbicide paraquat, the fungal toxin ochratoxin, and heavy metals) as well as pharmaceuticals (certain beta-lactam antibiotics, antiviral drugs, and chemotherapeutic drugs). This review explores the mechanisms by which transporters mediate the entry and exit of toxicants from renal tubule cells and influence the degree of kidney injury. Delineating how transport proteins regulate the renal accumulation of toxicants is critical for understanding the likelihood of nephrotoxicity resulting from competition for excretion or genetic polymorphisms that affect transporter function. Twit Text FOAVip Xenobiotic transporters and kidney injury ????Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=28111348 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28111348 #FOAvip English Wikipedia <ref>{{Cite pmid|28111348 }}</ref> Xenobiotic transporters and kidney injury #MMPMID28111348 George B ; You D ; Joy MS ; Aleksunes LM Adv Drug Deliv Rev 2017[Jul]; 116 (ä): 73-91 PMID28111348 show ga Renal proximal tubules are targets for toxicity due in part to the expression of transporters that mediate the secretion and reabsorption of xenobiotics. Alterations in transporter expression and/or function can enhance the accumulation of toxicants and sensitize the kidneys to injury. This can be observed when xenobiotic uptake by carrier proteins is increased or efflux of toxicants and their metabolites is reduced. Nephrotoxic chemicals include environmental contaminants (halogenated hydrocarbon solvents, the herbicide paraquat, the fungal toxin ochratoxin, and heavy metals) as well as pharmaceuticals (certain beta-lactam antibiotics, antiviral drugs, and chemotherapeutic drugs). This review explores the mechanisms by which transporters mediate the entry and exit of toxicants from renal tubule cells and influence the degree of kidney injury. Delineating how transport proteins regulate the renal accumulation of toxicants is critical for understanding the likelihood of nephrotoxicity resulting from competition for excretion or genetic polymorphisms that affect transporter function. |*Kidney/metabolism/pathology [MESH] |*Membrane Transport Proteins [MESH] |Animals [MESH] |Carrier Proteins [MESH] |Humans [MESH]Xenobiotic transporters and kidney injury (epmc).pdf DeepDyve Pubget Overpricing