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2017 ; 2017
(ä): 5295286
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Wnt5a Signaling in Normal and Cancer Stem Cells
#MMPMID28491097
Zhou Y
; Kipps TJ
; Zhang S
Stem Cells Int
2017[]; 2017
(ä): 5295286
PMID28491097
show ga
Wnt5a is involved in activating several noncanonical Wnt signaling pathways,
which can inhibit or activate canonical Wnt/?-catenin signaling pathway in a
receptor context-dependent manner. Wnt5a signaling is critical for regulating
normal developmental processes, including stem cell self-renewal, proliferation,
differentiation, migration, adhesion, and polarity. Moreover, the aberrant
activation or inhibition of Wnt5a signaling is emerging as an important event in
cancer progression, exerting both oncogenic and tumor suppressive effects. Recent
studies show the involvement of Wnt5a signaling in regulating normal and cancer
stem cell self-renewal, cancer cell proliferation, migration, and invasion. In
this article, we review recent findings regarding the molecular mechanisms and
roles of Wnt5a signaling in stem cells in embryogenesis and in the normal or
neoplastic breast or ovary, highlighting that Wnt5a may have different effects on
target cells depending on the surface receptors expressed by the target cell.