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10.1186/s13045-017-0471-6 http://scihub22266oqcxt.onion/10.1186/s13045-017-0471-6 C5420131!5420131 !28476164     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28476164 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Hematol+Oncol 2017 ; 10 (1 ): 101 Nephropedia Template TP {{tp|p=28476164 |t=2017. Wnt/beta-catenin pathway: modulating anticancer immune response |pdf=|usr=}}{{28476164 }} gab.com Text Wnt/beta-catenin pathway: modulating anticancer immune response JO: J Hematol Oncol http://www.kidney.de/pget.php?&tw=1&pmid=28476164 #FOAvip Wnt/?-catenin signaling, a highly conserved pathway through evolution, regulates key cellular functions including proliferation, differentiation, migration, genetic stability, apoptosis, and stem cell renewal. The Wnt pathway mediates biological processes by a canonical or noncanonical pathway, depending on the involvement of ?-catenin in signal transduction. ?-catenin is a core component of the cadherin protein complex, whose stabilization is essential for the activation of Wnt/?-catenin signaling. As multiple aberrations in this pathway occur in numerous cancers, WNT-directed therapy represents an area of significant developmental therapeutics focus. The recently described role of Wnt/?-catenin pathway in regulating immune cell infiltration of the tumor microenvironment renewed the interest, given its potential impact on responses to immunotherapy treatments. This article summarizes the role of Wnt/?-catenin pathway in cancer and ongoing therapeutic strategies involving this pathway. Twit Text FOAVip Wnt/beta-catenin pathway: modulating anticancer immune response ????J Hematol Oncol http://www.kidney.de/pget.php?&tw=1&pmid=28476164 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28476164 #FOAvip English Wikipedia <ref>{{Cite pmid|28476164 }}</ref> Wnt/beta-catenin pathway: modulating anticancer immune response #MMPMID28476164 Pai SG ; Carneiro BA ; Mota JM ; Costa R ; Leite CA ; Barroso-Sousa R ; Kaplan JB ; Chae YK ; Giles FJ J Hematol Oncol 2017[May]; 10 (1 ): 101 PMID28476164 show ga Wnt/?-catenin signaling, a highly conserved pathway through evolution, regulates key cellular functions including proliferation, differentiation, migration, genetic stability, apoptosis, and stem cell renewal. The Wnt pathway mediates biological processes by a canonical or noncanonical pathway, depending on the involvement of ?-catenin in signal transduction. ?-catenin is a core component of the cadherin protein complex, whose stabilization is essential for the activation of Wnt/?-catenin signaling. As multiple aberrations in this pathway occur in numerous cancers, WNT-directed therapy represents an area of significant developmental therapeutics focus. The recently described role of Wnt/?-catenin pathway in regulating immune cell infiltration of the tumor microenvironment renewed the interest, given its potential impact on responses to immunotherapy treatments. This article summarizes the role of Wnt/?-catenin pathway in cancer and ongoing therapeutic strategies involving this pathway. |*Immunotherapy [MESH] |*Molecular Targeted Therapy [MESH] |Acyltransferases/antagonists & inhibitors [MESH] |Antineoplastic Agents/*pharmacology/therapeutic use [MESH] |Antineoplastic Combined Chemotherapy Protocols/therapeutic use [MESH] |Cell Communication/drug effects [MESH] |Clinical Trials as Topic [MESH] |Humans [MESH] |Immunotherapy, Adoptive [MESH] |Macrophages/drug effects [MESH] |Membrane Proteins/antagonists & inhibitors [MESH] |Neoplasm Proteins/*antagonists & inhibitors/physiology [MESH] |Neoplasms/*drug therapy/immunology [MESH] |Observational Studies as Topic [MESH] |T-Lymphocyte Subsets/immunology [MESH] |Tankyrases/antagonists & inhibitors [MESH] |Tumor Escape/drug effects/immunology [MESH] |Tumor Microenvironment [MESH] |Wnt Proteins/*antagonists & inhibitors/physiology [MESH] |Wnt Signaling Pathway/*drug effects [MESH] |Wnt-5a Protein/agonists [MESH]Wnt/beta-catenin pathway: modulating anticancer immune response (epmc).pdf DeepDyve Pubget Overpricing