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2017 ; 6
(ä): 746
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Wnt target genes and where to find them
#MMPMID28649368
Ramakrishnan AB
; Cadigan KM
F1000Res
2017[]; 6
(ä): 746
PMID28649368
show ga
Wnt/?-catenin signaling is highly conserved throughout metazoans, is required for
numerous essential events in development, and serves as a stem cell niche signal
in many contexts. Misregulation of the pathway is linked to several human
pathologies, most notably cancer. Wnt stimulation results in stabilization and
nuclear import of ?-catenin, which then acts as a transcriptional co-activator.
Transcription factors of the T-cell family (TCF) are the best-characterized
nuclear binding partners of ?-catenin and mediators of Wnt gene regulation. This
review provides an update on what is known about the transcriptional activation
of Wnt target genes, highlighting recent work that modifies the conventional
model. Wnt/?-catenin signaling regulates genes in a highly context-dependent
manner, and the role of other signaling pathways and TCF co-factors in this
process will be discussed. Understanding Wnt gene regulation has served to
elucidate many biological roles of the pathway, and we will use examples from
stem cell biology, metabolism, and evolution to illustrate some of the rich Wnt
biology that has been uncovered.
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