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10.1895/wormbook.1.7.1 http://scihub22266oqcxt.onion/10.1895/wormbook.1.7.1 C4781570!4781570 !18050402     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=18050402 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\18050402 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       WormBook 2005 ; ä (ä): 1-17 Nephropedia Template TP {{tp|p=18050402 |t=2005. Wnt signaling |pdf=|usr=}}{{18050402 }} gab.com Text Wnt signaling JO: WormBook http://www.kidney.de/pget.php?&tw=1&pmid=18050402 #FOAvip The use of Wnt ligands for signaling between cells is a conserved feature of metazoan development. Activation of Wnt signal transduction pathways upon ligand binding can regulate diverse processes including cell proliferation, migration, polarity, differentiation and axon outgrowth. A 'canonical' Wnt signaling pathway has been elucidated in vertebrate and invertebrate model systems. In the canonical pathway, Wnt binding leads to the stabilization of the transcription factor beta-catenin, which enters the nucleus to regulate Wnt pathway target genes. However, Wnt binding also acts through beta-catenin-independent, noncanonical pathways, such as the planar cell polarity (PCP) pathway and a pathway involving Ca2+ signaling. This chapter examines our current understanding of Wnt signaling and Wnt-mediated processes in the nematode C. elegans. Like other species, the C. elegans genome encodes multiple genes for Wnt ligands (five) and Wnt receptors (four frizzleds, one Ryk/Derailed). Unlike vertebrates or Drosophila, the C. elegans genome encodes three beta-catenin genes, which appear to have distinct functions in Wnt signaling and cell adhesion. Canonical Wnt signaling clearly exists in C. elegans, utilizing the beta-catenin BAR-1. However, a noncanonical pathway utilizing the beta-catenin WRM-1 also exists, and to date a similar pathway has not been described in other species. Evidence for beta-catenin independent noncanonical Wnt signaling is currently limited. The role of Wnt signaling in over a dozen C. elegans developmental processes, including the regulation of cell fate, polarity and migration, is described. Twit Text FOAVip Wnt signaling ????WormBook http://www.kidney.de/pget.php?&tw=1&pmid=18050402 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18050402 #FOAvip English Wikipedia <ref>{{Cite pmid|18050402 }}</ref> Wnt signaling #MMPMID18050402 Eisenmann DM WormBook 2005[Jun]; ä (ä): 1-17 PMID18050402 show ga The use of Wnt ligands for signaling between cells is a conserved feature of metazoan development. Activation of Wnt signal transduction pathways upon ligand binding can regulate diverse processes including cell proliferation, migration, polarity, differentiation and axon outgrowth. A 'canonical' Wnt signaling pathway has been elucidated in vertebrate and invertebrate model systems. In the canonical pathway, Wnt binding leads to the stabilization of the transcription factor beta-catenin, which enters the nucleus to regulate Wnt pathway target genes. However, Wnt binding also acts through beta-catenin-independent, noncanonical pathways, such as the planar cell polarity (PCP) pathway and a pathway involving Ca2+ signaling. This chapter examines our current understanding of Wnt signaling and Wnt-mediated processes in the nematode C. elegans. Like other species, the C. elegans genome encodes multiple genes for Wnt ligands (five) and Wnt receptors (four frizzleds, one Ryk/Derailed). Unlike vertebrates or Drosophila, the C. elegans genome encodes three beta-catenin genes, which appear to have distinct functions in Wnt signaling and cell adhesion. Canonical Wnt signaling clearly exists in C. elegans, utilizing the beta-catenin BAR-1. However, a noncanonical pathway utilizing the beta-catenin WRM-1 also exists, and to date a similar pathway has not been described in other species. Evidence for beta-catenin independent noncanonical Wnt signaling is currently limited. The role of Wnt signaling in over a dozen C. elegans developmental processes, including the regulation of cell fate, polarity and migration, is described. |Animals [MESH] |Caenorhabditis elegans Proteins/*metabolism [MESH] |Caenorhabditis elegans/*metabolism [MESH] |Cytoskeletal Proteins/metabolism [MESH] |Signal Transduction/*physiology [MESH]Wnt signaling (epmc).pdf DeepDyve Pubget Overpricing