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2017 ; 36
(11
): 1461-1473
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Wnt signaling in cancer
#MMPMID27617575
Zhan T
; Rindtorff N
; Boutros M
Oncogene
2017[Mar]; 36
(11
): 1461-1473
PMID27617575
show ga
Wnt signaling is one of the key cascades regulating development and stemness, and
has also been tightly associated with cancer. The role of Wnt signaling in
carcinogenesis has most prominently been described for colorectal cancer, but
aberrant Wnt signaling is observed in many more cancer entities. Here, we review
current insights into novel components of Wnt pathways and describe their impact
on cancer development. Furthermore, we highlight expanding functions of Wnt
signaling for both solid and liquid tumors. We also describe current findings how
Wnt signaling affects maintenance of cancer stem cells, metastasis and immune
control. Finally, we provide an overview of current strategies to antagonize Wnt
signaling in cancer and challenges that are associated with such approaches.
|*Wnt Signaling Pathway/drug effects
[MESH]
|Animals
[MESH]
|Antineoplastic Agents/pharmacology/therapeutic use
[MESH]