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2008 ; 9
(7
): 558-64
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Wnt signaling in angiogenesis
#MMPMID18673241
Parmalee NL
; Kitajewski J
Curr Drug Targets
2008[Jul]; 9
(7
): 558-64
PMID18673241
show ga
Although progress has been made in understanding the role of growth factors and
their receptors in angiogenesis, little is known about how the Wnt family of
growth factors function in the vasculature. Wnts are multifunctional factors that
act through the frizzled receptors to regulate proliferation, apoptosis,
branching morphogenesis, inductive processes, and cell polarity. All of these
processes must occur as developing vascular structures are formed and maintained.
Recent evidence has linked the Wnt/Frizzled signaling pathway to proper vascular
growth in murine and human retina. Here we review the literature describing the
angiogenic functions for Wnt signaling and focus on a newly discovered angiogenic
factor, Norrin, which acts through the Wnt receptor, Frizzled4.