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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Physiol
2016 ; 594
(17
): 4837-47
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Wnt pathway regulation of intestinal stem cells
#MMPMID27581568
Mah AT
; Yan KS
; Kuo CJ
J Physiol
2016[Sep]; 594
(17
): 4837-47
PMID27581568
show ga
Wnt signalling is involved in multiple aspects of embryonic development and adult
tissue homeostasis, notably via controlling cellular proliferation and
differentiation. Wnt signalling is subject to stringent positive and negative
regulation to promote proper development and homeostasis yet avoid aberrant
growth. Such multi-layer regulation includes post-translational modification and
processing of Wnt proteins themselves, R-spondin (Rspo) amplification of Wnt
signalling, diverse receptor families, and intracellular and extracellular
antagonists and destruction and transcription complexes. In the gastrointestinal
tract, Wnt signalling is crucial for development and renewal of the intestinal
epithelium. Intestinal stem cells (ISCs) undergo symmetric division and neutral
drift dynamics to renew the intestinal epithelium. Sources of Wnts and Wnt
amplifers such as R-spondins are beginning to be elucidated as well as their
functional contribution to intestinal homeostasis. In this review we focus on
regulation of ISCs and intestinal homeostasis by the Wnt/Rspo pathway, the
potential cellular sources of Wnt signalling regulators and highlight potential
future areas of study.