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2018 ; 9
(4
): ä Nephropedia Template TP
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Wnt Signalling in Gastrointestinal Epithelial Stem Cells
#MMPMID29570681
Flanagan DJ
; Austin CR
; Vincan E
; Phesse TJ
Genes (Basel)
2018[Mar]; 9
(4
): ä PMID29570681
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Wnt signalling regulates several cellular functions including proliferation,
differentiation, apoptosis and migration, and is critical for embryonic
development. Stem cells are defined by their ability for self-renewal and the
ability to be able to give rise to differentiated progeny. Consequently, they are
essential for the homeostasis of many organs including the gastrointestinal
tract. This review will describe the huge advances in our understanding of how
stem cell functions in the gastrointestinal tract are regulated by Wnt
signalling, including how deregulated Wnt signalling can hijack these functions
to transform cells and lead to cancer.