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2016 ; 32
(2
): 123-34
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Wnt Signaling: Role in Regulation of Haematopoiesis
#MMPMID27065573
Undi RB
; Gutti U
; Sahu I
; Sarvothaman S
; Pasupuleti SR
; Kandi R
; Gutti RK
Indian J Hematol Blood Transfus
2016[Jun]; 32
(2
): 123-34
PMID27065573
show ga
Hematopoietic stem cells (HSCs) are a unique population of bone marrow cells
which are responsible for the generation of various blood cell lineages. One of
the significant characteristics of these HSCs is to self-renew, while producing
differentiating cells for normal hematopoiesis. Deregulation of self-renewal and
differentiation leads to the hematological malignancies. Several pathways are
known to be involved in the maintenance of HSC fate among which Wnt signaling is
a crucial pathway which controls development and cell fate determination. Wnt
signaling also plays a major role in differentiation, self-renewal and
maintenance of HSCs. Wnt ligands activate three major pathways including planar
cell polarity, Wnt/?-catenin and Wnt/Ca(2+). It has been shown that Wnt/?-catenin
or canonical pathway regulates cell proliferation, survival and differentiation
in HSCs, deregulation of this pathway leads to hematological malignancies. Wnt
non-canonical pathway regulates calcium signaling and planar cell polarity. In
this review, we discuss various signaling pathways induced by Wnt ligands and
their potential role in hematopoiesis.
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