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Within the Brain: The Renin Angiotensin System
#MMPMID29543776
Jackson L
; Eldahshan W
; Fagan SC
; Ergul A
Int J Mol Sci
2018[Mar]; 19
(3
): ? PMID29543776
show ga
For many years, modulators of the renin angiotensin system (RAS) have been
trusted by clinicians for the control of essential hypertension. It was recently
demonstrated that these modulators have other pleiotropic properties independent
of their hypotensive effects, such as enhancement of cognition. Within the brain,
different components of the RAS have been extensively studied in the context of
neuroprotection and cognition. Interestingly, a crosstalk between the RAS and
other systems such as cholinergic, dopaminergic and adrenergic systems have been
demonstrated. In this review, the preclinical and clinical evidence for the
impact of RAS modulators on cognitive impairment of multiple etiologies will be
discussed. In addition, the expression and function of different receptor
subtypes within the RAS such as: Angiotensin II type I receptor (AT1R),
Angiotensin II type II receptor (AT2R), Angiotensin IV receptor (AT4R), Mas
receptor (MasR), and Mas-related-G protein-coupled receptor (MrgD), on different
cell types within the brain will be presented. We aim to direct the attention of
the scientific community to the plethora of evidence on the importance of the RAS
on cognition and to the different disease conditions in which these agents can be
beneficial.
|*Renin-Angiotensin System
[MESH]
|Angiotensin Receptor Antagonists/pharmacology/therapeutic use
[MESH]
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