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2017 ; 7
(ä): 43292
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When to stop propranolol for infantile hemangioma
#MMPMID28225076
Chang L
; Gu Y
; Yu Z
; Ying H
; Qiu Y
; Ma G
; Chen H
; Jin Y
; Lin X
Sci Rep
2017[Feb]; 7
(ä): 43292
PMID28225076
show ga
There is no definitive conclusion regarding the optimal timing for terminating
propranolol treatment for infantile hemangioma (IH). A total of 149 patients who
underwent detailed color Doppler ultrasound examination were included in this
study. The characteristics and propranolol treatment of all patients were
summarized and analyzed. Patients were divided into two groups according to the
lesion regression rate. Among the 149 patients, 38 were assigned to the complete
regression group, and 111 were assigned to the partial regression group. The age
at which propranolol treatment started, duration of follow-up after treatment
discontinuation and rate of adverse events were not significantly different
between the two groups. The duration of oral propranolol treatment was shorter in
the complete regression group. The age at which propranolol was terminated was
younger in the complete regression group, and this group had a lower recurrence
rate. Propranolol is safe and effective for the treatment of IHs that require
intervention, but it should be stopped at an appropriate time, which is
determined primarily by the lesion regression rate after propranolol treatment.
Ultrasound is helpful in determining when to stop propranolol for IH.
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