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2016 ; 62
(5
): 777-87
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When Genome Maintenance Goes Badly Awry
#MMPMID27259208
Kass EM
; Moynahan ME
; Jasin M
Mol Cell
2016[Jun]; 62
(5
): 777-87
PMID27259208
show ga
Genetic abnormalities are present in all tumor types, although the frequency and
type can vary. Chromosome abnormalities include highly aberrant structures,
particularly chromothriptic chromosomes. The generation of massive sequencing
data has illuminated the scope of the mutational burden in cancer genomes,
identifying patterns of mutations (mutation signatures), which have the potential
to shed light on the relatedness and etiologies of cancers and impact therapy
response. Some mutation patterns are clearly attributable to disruptions in
pathways that maintain genomic integrity. Here we review recent advances in our
understanding of genetic changes occurring in cancers and the roles of genome
maintenance pathways.
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