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10.1016/j.molcel.2016.05.021 http://scihub22266oqcxt.onion/10.1016/j.molcel.2016.05.021 C4966655!4966655!27259208     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27259208.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Cell 2016 ; 62 (5): 777-87 Nephropedia Template TP {{tp|p=27259208|t=2016. When genome maintenance goes (badly) awry |pdf=|usr=}}{{27259208}} gab.com Text When genome maintenance goes (badly) awry JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=27259208 #FOAvip Genetic abnormalities are present in all tumor types, although the frequency and type can vary. Chromosome abnormalities include highly aberrant structures, particularly chromothriptic chromosomes. The generation of massive sequencing data has illuminated the scope of the mutational burden in cancer genomes, identifying patterns of mutations (mutation signatures), which have the potential to shed light on the relatedness and etiologies of cancers and impact therapy response. Some mutation patterns are clearly attributable to disruptions in pathways that maintain genomic integrity. Here we review recent advances in our understanding of genetic changes occurring in cancers and the roles of genome maintenance pathways. Twit Text FOAVip When genome maintenance goes (badly) awry ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=27259208 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27259208 #FOAvip English Wikipedia <ref>{{Cite pmid|27259208}}</ref> When genome maintenance goes (badly) awry #MMPMID27259208 Kass EM; Moynahan ME; Jasin M Mol Cell 2016[Jun]; 62 (5): 777-87 PMID27259208show ga Genetic abnormalities are present in all tumor types, although the frequency and type can vary. Chromosome abnormalities include highly aberrant structures, particularly chromothriptic chromosomes. The generation of massive sequencing data has illuminated the scope of the mutational burden in cancer genomes, identifying patterns of mutations (mutation signatures), which have the potential to shed light on the relatedness and etiologies of cancers and impact therapy response. Some mutation patterns are clearly attributable to disruptions in pathways that maintain genomic integrity. Here we review recent advances in our understanding of genetic changes occurring in cancers and the roles of genome maintenance pathways. äWhen genome maintenance goes (badly) awry (epmc).pdf DeepDyve Pubget Overpricing