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10.1016/j.cell.2016.08.028 http://scihub22266oqcxt.onion/10.1016/j.cell.2016.08.028 C5062957!5062957 !27616062     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27616062 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27616062 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell 2016 ; 167 (1 ): 47-59.e15 Nephropedia Template TP {{tp|p=27616062 |t=2016. Warm-Sensitive Neurons that Control Body Temperature |pdf=|usr=}}{{27616062 }} gab.com Text Warm-Sensitive Neurons that Control Body Temperature JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=27616062 #FOAvip Thermoregulation is one of the most vital functions of the brain, but how temperature information is converted into homeostatic responses remains unknown. Here, we use an unbiased approach for activity-dependent RNA sequencing to identify warm-sensitive neurons (WSNs) within the preoptic hypothalamus that orchestrate the homeostatic response to heat. We show that these WSNs are molecularly defined by co-expression of the neuropeptides BDNF and PACAP. Optical recordings in awake, behaving mice reveal that these neurons are selectively activated by environmental warmth. Optogenetic excitation of WSNs triggers rapid hypothermia, mediated by reciprocal changes in heat production and loss, as well as dramatic cold-seeking behavior. Projection-specific manipulations demonstrate that these distinct effectors are controlled by anatomically segregated pathways. These findings reveal a molecularly defined cell type that coordinates the diverse behavioral and autonomic responses to heat. Identification of these warm-sensitive cells provides genetic access to the core neural circuit regulating the body temperature of mammals. PAPERCLIP. Twit Text FOAVip Warm-Sensitive Neurons that Control Body Temperature ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=27616062 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27616062 #FOAvip English Wikipedia <ref>{{Cite pmid|27616062 }}</ref> Warm-Sensitive Neurons that Control Body Temperature #MMPMID27616062 Tan CL ; Cooke EK ; Leib DE ; Lin YC ; Daly GE ; Zimmerman CA ; Knight ZA Cell 2016[Sep]; 167 (1 ): 47-59.e15 PMID27616062 show ga Thermoregulation is one of the most vital functions of the brain, but how temperature information is converted into homeostatic responses remains unknown. Here, we use an unbiased approach for activity-dependent RNA sequencing to identify warm-sensitive neurons (WSNs) within the preoptic hypothalamus that orchestrate the homeostatic response to heat. We show that these WSNs are molecularly defined by co-expression of the neuropeptides BDNF and PACAP. Optical recordings in awake, behaving mice reveal that these neurons are selectively activated by environmental warmth. Optogenetic excitation of WSNs triggers rapid hypothermia, mediated by reciprocal changes in heat production and loss, as well as dramatic cold-seeking behavior. Projection-specific manipulations demonstrate that these distinct effectors are controlled by anatomically segregated pathways. These findings reveal a molecularly defined cell type that coordinates the diverse behavioral and autonomic responses to heat. Identification of these warm-sensitive cells provides genetic access to the core neural circuit regulating the body temperature of mammals. PAPERCLIP. |*Gene Expression Regulation [MESH] |*Hot Temperature [MESH] |Animals [MESH] |Behavior, Animal [MESH] |Body Temperature Regulation/*genetics [MESH] |Brain-Derived Neurotrophic Factor/*genetics [MESH] |Mice [MESH] |Microdissection [MESH] |Neurons/metabolism/*physiology [MESH] |Optogenetics [MESH] |Pituitary Adenylate Cyclase-Activating Polypeptide/*genetics [MESH] |RNA, Messenger/genetics [MESH] |Ribosomal Protein S6/metabolism [MESH] |Sequence Analysis, RNA [MESH]Warm-Sensitive Neurons that Control Body Temperature (epmc).pdf DeepDyve Pubget Overpricing