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2018 ; 8
(4
): 40
Nephropedia Template TP
Blood Cancer J
2018[May]; 8
(4
): 40
PMID29712895
show ga
Waldenström macroglobulinemia is often an indolent disorder, and many patients
are candidates for observation with careful monitoring. For symptomatic patients,
one must distinguish between those patients whose symptoms are related to
immunologic manifestations associated with the IgM monoclonal protein and those
that have symptoms related to progressive marrow and nodal infiltration with
lymphoplasmacytic lymphoma. In Waldenström macroglobulinemia, the driver for
therapy in the majority of patients is progressive anemia, secondary to bone
marrow replacement by lymphoplasmacytic lymphoma. Recent introduction of MYD88
mutational analysis has been very useful for diagnostic purposes but is unclear
what effect it might have on the prognosis or response rate to therapy. An
algorithm is provided on the management of asymptomatic individuals and the
sequence used for chemotherapeutic intervention of symptomatic patients.
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