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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Clin+Lymphoma+Myeloma+Leuk
2017 ; 17
(5
): 252-262
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Waldenström Macroglobulinemia: Review of Pathogenesis and Management
#MMPMID28366781
Yun S
; Johnson AC
; Okolo ON
; Arnold SJ
; McBride A
; Zhang L
; Baz RC
; Anwer F
Clin Lymphoma Myeloma Leuk
2017[May]; 17
(5
): 252-262
PMID28366781
show ga
Waldenström macroglobulinemia (WM) is a low-grade B-cell clonal disorder
characterized by lymphoplasmacytic bone marrow involvement associated with
monoclonal immunoglobulin M. Although WM remains to be an incurable disease with
a heterogeneous clinical course, the recent discovery of mutations in the MYD88
and CXCR4 genes further enhanced our understanding of its pathogenesis.
Development of new therapies including monoclonal antibodies, proteasome
inhibitors, and Bruton tyrosine kinase inhibitors have made the management of WM
increasingly complex. Treatment should be tailored to the individual patient
while considering many clinical factors. The clinical outcomes are expected to
continue to improve, given the emergence of novel therapeutics and better
understanding of the underlying pathogenesis.