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2014 ; 18
(11
): 849-852
Nephropedia Template TP
Atlas Genet Cytogenet Oncol Haematol
2014[Nov]; 18
(11
): 849-852
PMID26366208
show ga
WWTR1 (also called TAZ in publications. Therefore, TAZ is used in the following
description) is a WW domaing-containing transcriptional coactivator, which was
first identified as a 14-3-3 binding protein. TAZ is the downstream component in
the Hippo pathway, and also has been found to interact with different pathways,
such as Wnt, TGFbeta, etc. TAZ is involved in mesenchymal stem cell
differentiation as well as tumorigenesis. High level of TAZ has been found in
different cancers, such as breast cancer, colon cancer, lung cancer, etc.