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10.4161/23723548.2014.965640

http://scihub22266oqcxt.onion/10.4161/23723548.2014.965640
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C4904998!4904998 !27308416
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suck abstract from ncbi


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pmid27308416
      Mol+Cell+Oncol 2015 ; 2 (2 ): e965640
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  • WWOX loss activates aerobic glycolysis #MMPMID27308416
  • Abu-Remaileh M ; Seewaldt VL ; Aqeilan RI
  • Mol Cell Oncol 2015[Apr]; 2 (2 ): e965640 PMID27308416 show ga
  • Cancer cells undergo reprogramming of glucose metabolism to limit energy production to glycolysis-a state known as "aerobic glycolysis." Hypoxia-inducible factor 1 (HIF1?) is a transcription factor that regulates many genes responsible for this switch. As discussed here, new data suggest that the tumor suppressor WW domain-containing oxidoreductase (WWOX) modulates HIF1?, thereby regulating this metabolic state.
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