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10.1080/23723556.2015.1008288

http://scihub22266oqcxt.onion/10.1080/23723556.2015.1008288
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suck abstract from ncbi


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pmid27308504
      Mol+Cell+Oncol 2015 ; 2 (4 ): e1008288
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  • WWOX guards genome stability by activating ATM #MMPMID27308504
  • Hazan I ; Abu-Odeh M ; Hofmann TG ; Aqeilan RI
  • Mol Cell Oncol 2015[Oct]; 2 (4 ): e1008288 PMID27308504 show ga
  • Common fragile sites (CFSs) tend to break upon replication stress and have been suggested to be "hot spots" for genomic instability. Recent evidence, however, implies that in the wake of DNA damage, WW domain-containing oxidoreductase (WWOX, the gene product of the FRA16D fragile site), associates with ataxia telangiectasia-mutated (ATM) and regulates its activation to maintain genomic integrity.
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