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10.1101/gad.268128.115 http://scihub22266oqcxt.onion/10.1101/gad.268128.115 C4647558!4647558 !26545811     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26545811 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Genes+Dev 2015 ; 29 (21 ): 2244-57 Nephropedia Template TP {{tp|p=26545811 |t=2015. WSB1 promotes tumor metastasis by inducing pVHL degradation |pdf=|usr=}}{{26545811 }} gab.com Text WSB1 promotes tumor metastasis by inducing pVHL degradation JO: Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=26545811 #FOAvip The von Hippel-Lindau tumor suppressor pVHL is an E3 ligase that targets hypoxia-inducible factors (HIFs). Mutation of VHL results in HIF up-regulation and contributes to processes related to tumor progression such as invasion, metastasis, and angiogenesis. However, very little is known with regard to post-transcriptional regulation of pVHL. Here we show that WD repeat and SOCS box-containing protein 1 (WSB1) is a negative regulator of pVHL through WSB1's E3 ligase activity. Mechanistically, WSB1 promotes pVHL ubiquitination and proteasomal degradation, thereby stabilizing HIF under both normoxic and hypoxic conditions. As a consequence, WSB1 up-regulates the expression of HIF-1?'s target genes and promotes cancer invasion and metastasis through its effect on pVHL. Consistent with this, WSB1 protein level negatively correlates with pVHL level and metastasis-free survival in clinical samples. This work reveals a new mechanism of pVHL's regulation by which cancer acquires invasiveness and metastatic tendency. Twit Text FOAVip WSB1 promotes tumor metastasis by inducing pVHL degradation ????Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=26545811 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26545811 #FOAvip English Wikipedia <ref>{{Cite pmid|26545811 }}</ref> WSB1 promotes tumor metastasis by inducing pVHL degradation #MMPMID26545811 Kim JJ ; Lee SB ; Jang J ; Yi SY ; Kim SH ; Han SA ; Lee JM ; Tong SY ; Vincelette ND ; Gao B ; Yin P ; Evans D ; Choi DW ; Qin B ; Liu T ; Zhang H ; Deng M ; Jen J ; Zhang J ; Wang L ; Lou Z Genes Dev 2015[Nov]; 29 (21 ): 2244-57 PMID26545811 show ga The von Hippel-Lindau tumor suppressor pVHL is an E3 ligase that targets hypoxia-inducible factors (HIFs). Mutation of VHL results in HIF up-regulation and contributes to processes related to tumor progression such as invasion, metastasis, and angiogenesis. However, very little is known with regard to post-transcriptional regulation of pVHL. Here we show that WD repeat and SOCS box-containing protein 1 (WSB1) is a negative regulator of pVHL through WSB1's E3 ligase activity. Mechanistically, WSB1 promotes pVHL ubiquitination and proteasomal degradation, thereby stabilizing HIF under both normoxic and hypoxic conditions. As a consequence, WSB1 up-regulates the expression of HIF-1?'s target genes and promotes cancer invasion and metastasis through its effect on pVHL. Consistent with this, WSB1 protein level negatively correlates with pVHL level and metastasis-free survival in clinical samples. This work reveals a new mechanism of pVHL's regulation by which cancer acquires invasiveness and metastatic tendency. |*Gene Expression Regulation, Neoplastic [MESH] |*Neoplasm Metastasis [MESH] |Cell Hypoxia [MESH] |Cell Line, Tumor [MESH] |Cell Movement/genetics [MESH] |HEK293 Cells [MESH] |HT29 Cells [MESH] |HeLa Cells [MESH] |Humans [MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/metabolism [MESH] |Intracellular Signaling Peptides and Proteins [MESH] |Mutation [MESH] |Neoplasm Invasiveness/genetics [MESH] |Neoplasms/genetics/physiopathology [MESH] |Proteasome Endopeptidase Complex/metabolism [MESH] |Protein Stability [MESH] |Protein Structure, Tertiary [MESH] |Proteins/genetics/*metabolism [MESH] |Ubiquitination [MESH]WSB1 promotes tumor metastasis by inducing pVHL degradation (epmc).pdf DeepDyve Pubget Overpricing