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10.1016/j.ccr.2014.07.018 http://scihub22266oqcxt.onion/10.1016/j.ccr.2014.07.018 C4159614!4159614 !25203320     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25203320 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cancer+Cell 2014 ; 26 (3 ): 309-317 Nephropedia Template TP {{tp|p=25203320 |t=2014. Vulnerabilities of mutant SWI/SNF complexes in cancer |pdf=|usr=}}{{25203320 }} gab.com Text Vulnerabilities of mutant SWI/SNF complexes in cancer JO: Cancer Cell http://www.kidney.de/pget.php?&tw=1&pmid=25203320 #FOAvip Cancer genome sequencing efforts have revealed the novel theme that chromatin modifiers are frequently mutated across a wide spectrum of cancers. Mutations in genes encoding subunits of SWI/SNF (BAF) chromatin remodeling complexes are particularly prevalent, occurring in 20% of all human cancers. As these are typically loss-of-function mutations and not directly therapeutically targetable, central goals have been to elucidate mechanism and identify vulnerabilities created by these mutations. Here, we discuss emerging data that these mutations lead to the formation of aberrant residual SWI/SNF complexes that constitute a specific vulnerability and discuss the potential for exploiting these dependencies in SWI/SNF mutant cancers. Twit Text FOAVip Vulnerabilities of mutant SWI/SNF complexes in cancer ????Cancer Cell http://www.kidney.de/pget.php?&tw=1&pmid=25203320 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25203320 #FOAvip English Wikipedia <ref>{{Cite pmid|25203320 }}</ref> Vulnerabilities of mutant SWI/SNF complexes in cancer #MMPMID25203320 Helming KC ; Wang X ; Roberts CWM Cancer Cell 2014[Sep]; 26 (3 ): 309-317 PMID25203320 show ga Cancer genome sequencing efforts have revealed the novel theme that chromatin modifiers are frequently mutated across a wide spectrum of cancers. Mutations in genes encoding subunits of SWI/SNF (BAF) chromatin remodeling complexes are particularly prevalent, occurring in 20% of all human cancers. As these are typically loss-of-function mutations and not directly therapeutically targetable, central goals have been to elucidate mechanism and identify vulnerabilities created by these mutations. Here, we discuss emerging data that these mutations lead to the formation of aberrant residual SWI/SNF complexes that constitute a specific vulnerability and discuss the potential for exploiting these dependencies in SWI/SNF mutant cancers. |Animals [MESH] |Antineoplastic Agents/pharmacology/therapeutic use [MESH] |Genetic Predisposition to Disease [MESH] |Humans [MESH] |Molecular Targeted Therapy [MESH] |Multiprotein Complexes/genetics [MESH] |Mutation [MESH] |Neoplasms/drug therapy/*genetics [MESH] |Protein Subunits/genetics [MESH]Vulnerabilities of mutant SWI/SNF complexes in cancer (epmc).pdf DeepDyve Pubget Overpricing