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2015 ; 8
(ä): 1761-71
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Volasertib for AML: clinical use and patient consideration
#MMPMID26229484
Hao Z
; Kota V
Onco Targets Ther
2015[]; 8
(ä): 1761-71
PMID26229484
show ga
Acute myeloid leukemia (AML) is a disease diagnosed mostly in patients >65 years
of age. Despite its heterogeneous nature, the different types of AMLs are still
managed by standard induction chemotherapy for those who can tolerate it in the
beginning. For the elderly and infirm patients, however, this approach leads to
unacceptably high induction mortality rate. This article reviews past and current
efforts searching for low-intensiveness treatments for the elderly and infirm
patients who cannot tolerate the standard induction regimen. Volasertib,
currently in Phase III clinical trials in combination with cytarabine, is
reviewed as a promising agent for this patient population with AML, from the
viewpoints of potential compliance and efficacy.