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2015 ; 17
(2
): 313-22
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Vitamin E transporters in cancer therapy
#MMPMID25466495
Alqahtani S
; Kaddoumi A
AAPS J
2015[Mar]; 17
(2
): 313-22
PMID25466495
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Besides their potent antioxidant activity, vitamin E isoforms demonstrated
multiple therapeutic activities among which is their activity against different
cancer types, including breast, prostate, and colon cancers. However, the
activity of vitamin E isoforms is limited by their low bioavailability following
oral administration. In addition to the low solubility, vitamin E isoforms have
been established as substrates for several intestinal and hepatic transport
proteins. In this review, we present reported anticancer activity of vitamin E
family members and the possible utilization of vitamin E and derivatives as
chemosensitizers to reverse multidrug resistance when given as part of a delivery
system and/or in combination with anticancer therapeutic drugs. Then, the review
discusses disposition of vitamin E members and transport proteins that play a
role in determining their systemic bioavailability followed by recent advances in
vitamin E formulations and delivery strategies.
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