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2016 ; 148
(3
): 227-36
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Vitamin D immunoregulation through dendritic cells
#MMPMID27040466
Bscheider M
; Butcher EC
Immunology
2016[Jul]; 148
(3
): 227-36
PMID27040466
show ga
Vitamin D (VD3) has been linked to immunological processes, and its
supplementation may have a role in treatment or prevention of diseases with
underlying autoimmune or pro-inflammatory states. As initiators of the immune
responses, dendritic cells (DC) are a potential target of VD3 to dampen
autoimmunity and inflammation, but the role of DC in VD3-mediated
immunomodulation in vivo is not understood. In addition to being targets of VD3,
DC can provide a local source of bioactive VD3 for regulation of T-cell
responses. Here we review existing studies that describe the tolerogenic
potential of VD3 on DC, and discuss them in the context of current understanding
of DC development and function. We speculate on mechanisms that might account for
the potent but poorly understood tolerogenic activities of VD3 and the role of DC
as both targets and sources of this hormone.