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2015 ; 14
(ä): 58
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Vitamin D & its analogues in type 2 diabetic nephropathy: a systematic review
#MMPMID26180775
Chokhandre MK
; Mahmoud MI
; Hakami T
; Jafer M
; Inamdar AS
J Diabetes Metab Disord
2015[]; 14
(ä): 58
PMID26180775
show ga
Nephropathy is one of the major complications of diabetes often leading to
chronic kidney disease (CKD). Inflammation and oxidative stress are associated
with pathogenesis of diabetic nephropathy (DN) and found to be regulated by
nuclear receptors such as vitamin D receptors (VDR). Vitamin D and its analogues
have been effectively used in patients with CKD. The review attempts to summarize
the available evidence on the role of vitamin D in DN. Electronic databases
(MEDLINE, EMBASE, and Cochrane Library) were searched for studies assessing the
role of vitamin D or its analogues on kidney function in type 2 diabetic
patients. Studies evaluating kidney functions (urinary albumin/protein creatinine
ratio, albuminuria and eGFR) were included and quality and risk of bias
assessment performed. Additionally effect on 25 (OH) vitamin D, calcium and HbA1c
were evaluated. The mean or its % change along with their standard deviation (SD)
was used for reporting our results. RevMan (V5.2) was used for data analysis. Six
studies included in this review evaluated the role of cholecalciferol, calcitriol
and paricalcitol in patients with DN. Study designs differed (three randomized,
one non-randomized and two uncontrolled trials) with varying degree of quality
and risk of biases. Vitamin D analogues showed significant improvement in kidney
function in two randomized studies. None of the studies reported significant
incidences of hypercalcemia. Vitamin D analogues show significant improvement of
kidney function in DN. Randomized controlled trials with longer duration,
comparing the efficacy of vitamin D and its analogues are needed.