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2017 ; 117
(15
): 10377-10402
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Virus-Derived Peptides for Clinical Applications
#MMPMID28723101
Yang M
; Sunderland K
; Mao C
Chem Rev
2017[Aug]; 117
(15
): 10377-10402
PMID28723101
show ga
Novel affinity agents with high specificity are needed to make progress in
disease diagnosis and therapy. Over the last several years, peptides have been
considered to have fundamental benefits over other affinity agents, such as
antibodies, due to their fast blood clearance, low immunogenicity, rapid tissue
penetration, and reproducible chemical synthesis. These features make peptides
ideal affinity agents for applications in disease diagnostics and therapeutics
for a wide variety of afflictions. Virus-derived peptide techniques provide a
rapid, robust, and high-throughput way to identify organism-targeting peptides
with high affinity and selectivity. Here, we will review viral peptide display
techniques, how these techniques have been utilized to select new
organism-targeting peptides, and their numerous biomedical applications with an
emphasis on targeted imaging, diagnosis, and therapeutic techniques. In the
future, these virus-derived peptides may be used as common diagnosis and
therapeutics tools in local clinics.
|*Molecular Targeted Therapy
[MESH]
|Humans
[MESH]
|Peptides/*metabolism/pharmacokinetics/*therapeutic use
[MESH]
free
free
free
