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2015 ; 8
(3
): 483-491
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Virus is a Signal for the Host Cell
#MMPMID26640606
Gómez J
; Ariza-Mateos A
; Cacho I
Biosemiotics
2015[]; 8
(3
): 483-491
PMID26640606
show ga
Currently, the concept of the cell as a society or an ecosystem of molecular
elements is gaining increasing acceptance. The basic idea arose in the 19th
century, from the surmise that there is not just a single unit underlying an
individual's appearance, but a plurality of entities with both collaborative and
conflicting relationships. The following hypothesis is based around this model.
The incompatible activities taking place between different original elements,
which were subsumed into the first cell and could not be eliminated, had to be
controlled very closely. Similarly, a strong level of control had to be developed
over many cellular elements after the cell changed its genome to DNA. We assume
that at least some of those original RNA agents and other biomolecules which
carry incompatibilities and risks, are retained within current cells, although
they are now under strict control. A virus functions as a signal informing these
repressed cellular RNAs and other elements of ancient origin how to restore
suppressed degrees of molecular freedom, favoring pre-existing molecular
affinities and activities, re-establishing ancient molecular webs of
interactions, and giving fragments of ancient coded information (mostly in the
form of RNA structural motifs) the opportunity to be re-expressed. Collectively,
these newly activated mechanisms lead to different possibilities for pathological
cell states. All these processes are opposed by cell-control mechanisms. Thus, in
this new scenario, the battle is considered intracellular rather than between the
virus and the cell. And so the virus is treated as the signal that precipitates
the cell's change from a latent to an active pathological state.
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