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10.1016/j.neuropharm.2016.02.013 http://scihub22266oqcxt.onion/10.1016/j.neuropharm.2016.02.013 C5929167!5929167 !26905292     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26905292 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26905292 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Neuropharmacology 2017 ; 120 (ä): 63-80 Nephropedia Template TP {{tp|p=26905292 |t=2017. Viral vectors for therapy of neurologic diseases |pdf=|usr=}}{{26905292 }} gab.com Text Viral vectors for therapy of neurologic diseases JO: Neuropharmacology http://www.kidney.de/pget.php?&tw=1&pmid=26905292 #FOAvip Neurological disorders - disorders of the brain, spine and associated nerves - are a leading contributor to global disease burden with a shockingly large associated economic cost. Various treatment approaches - pharmaceutical medication, device-based therapy, physiotherapy, surgical intervention, among others - have been explored to alleviate the resulting extent of human suffering. In recent years, gene therapy using viral vectors - encoding a therapeutic gene or inhibitory RNA into a "gutted" viral capsid and supplying it to the nervous system - has emerged as a clinically viable option for therapy of brain disorders. In this Review, we provide an overview of the current state and advances in the field of viral vector-mediated gene therapy for neurological disorders. Vector tools and delivery methods have evolved considerably over recent years, with the goal of providing greater and safer genetic access to the central nervous system. Better etiological understanding of brain disorders has concurrently led to identification of improved therapeutic targets. We focus on the vector technology, as well as preclinical and clinical progress made thus far for brain cancer and various neurodegenerative and neurometabolic disorders, and point out the challenges and limitations that accompany this new medical modality. Finally, we explore the directions that neurological gene therapy is likely to evolve towards in the future. This article is part of the Special Issue entitled "Beyond small molecules for neurological disorders". Twit Text FOAVip Viral vectors for therapy of neurologic diseases ????Neuropharmacology http://www.kidney.de/pget.php?&tw=1&pmid=26905292 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26905292 #FOAvip English Wikipedia <ref>{{Cite pmid|26905292 }}</ref> Viral vectors for therapy of neurologic diseases #MMPMID26905292 Choudhury SR ; Hudry E ; Maguire CA ; Sena-Esteves M ; Breakefield XO ; Grandi P Neuropharmacology 2017[Jul]; 120 (ä): 63-80 PMID26905292 show ga Neurological disorders - disorders of the brain, spine and associated nerves - are a leading contributor to global disease burden with a shockingly large associated economic cost. Various treatment approaches - pharmaceutical medication, device-based therapy, physiotherapy, surgical intervention, among others - have been explored to alleviate the resulting extent of human suffering. In recent years, gene therapy using viral vectors - encoding a therapeutic gene or inhibitory RNA into a "gutted" viral capsid and supplying it to the nervous system - has emerged as a clinically viable option for therapy of brain disorders. In this Review, we provide an overview of the current state and advances in the field of viral vector-mediated gene therapy for neurological disorders. Vector tools and delivery methods have evolved considerably over recent years, with the goal of providing greater and safer genetic access to the central nervous system. Better etiological understanding of brain disorders has concurrently led to identification of improved therapeutic targets. We focus on the vector technology, as well as preclinical and clinical progress made thus far for brain cancer and various neurodegenerative and neurometabolic disorders, and point out the challenges and limitations that accompany this new medical modality. Finally, we explore the directions that neurological gene therapy is likely to evolve towards in the future. This article is part of the Special Issue entitled "Beyond small molecules for neurological disorders". |Animals [MESH] |Brain Neoplasms/therapy [MESH] |Gene Transfer Techniques [MESH] |Genetic Therapy/*methods [MESH] |Genetic Vectors/physiology/*therapeutic use [MESH] |Humans [MESH]Viral vectors for therapy of neurologic diseases (epmc).pdf DeepDyve Pubget Overpricing