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2009 ; 1792
(7
): 714-21
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Viral parkinsonism
#MMPMID18760350
Jang H
; Boltz DA
; Webster RG
; Smeyne RJ
Biochim Biophys Acta
2009[Jul]; 1792
(7
): 714-21
PMID18760350
show ga
Parkinson's disease is a debilitating neurological disorder that affects 1-2% of
the adult population over 55 years of age. For the vast majority of cases, the
etiology of this disorder is unknown, although it is generally accepted that
there is a genetic susceptibility to any number of environmental agents. One such
agent may be viruses. It has been shown that numerous viruses can enter the
nervous system, i.e. they are neurotropic, and induce a number of
encephalopathies. One of the secondary consequences of these encephalopathies can
be parkinsonism, that is both transient as well as permanent. One of the most
highlighted and controversial cases of viral parkinsonism is that which followed
the 1918 influenza outbreak and the subsequent induction of von Economo's
encephalopathy. In this review, we discuss the neurological sequelae of infection
by influenza virus as well as that of other viruses known to induce parkinsonism
including Coxsackie, Japanese encephalitis B, St. Louis, West Nile and HIV
viruses.
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