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2018 ; 13
(3
): 211-223
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Viral manipulation of host mRNA decay
#MMPMID29750084
Guo L
; Vlasova-St Louis I
; Bohjanen PR
Future Virol
2018[Mar]; 13
(3
): 211-223
PMID29750084
show ga
Viruses alter host-cell gene expression at many biochemical levels, such as
transcription, translation, mRNA splicing and mRNA decay in order to create a
cellular environment suitable for viral replication. In this review, we discuss
mechanisms by which viruses manipulate host-gene expression at the level of mRNA
decay in order to enable the virus to evade host antiviral responses to allow
viral survival and replication. We discuss different cellular RNA decay pathways,
including the deadenylation-dependent mRNA decay pathway, and various strategies
that viruses exploit to manipulate these pathways in order to create a
virus-friendly cellular environment.