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10.1038/nrmicro.2016.45 http://scihub22266oqcxt.onion/10.1038/nrmicro.2016.45 C5072394!5072394!27174148     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27174148.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Rev+Microbiol 2016 ; 14 (6): 360-73 Nephropedia Template TP {{tp|p=27174148|t=2016. Viral evasion of intracellular DNA and RNA sensing |pdf=|usr=}}{{27174148}} gab.com Text Viral evasion of intracellular DNA and RNA sensing JO: Nat Rev Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=27174148 #FOAvip Germline-encoded pattern recognition receptors (PRRs) mediate an early innate immune response against viral pathogens.Retinoic acid-inducible gene I protein (RIG-I) and melanoma differentiation-associated protein 5 (MDA5) are cytoplasmic sensors that detect viral RNA species and signal through the mitochondrial antiviral-signalling protein (MAVS) to induce the production of type I interferons (IFNs) and other cytokines.Intracellular DNA sensors, such as cyclic GMP?AMP synthase (cGAS) and IFN?-inducible protein 16 (IFI16), detect viral DNA in the cytoplasm and/or nucleus and signal through the stimulator of IFN genes (STING) to trigger an immune response.Viruses antagonize PRRs through the sequestration or modification of their viral genomes and through the manipulation of post-translational modifications of PRRs or their adaptor proteins. Some viruses cleave or degrade PRRs or their adaptors, or sequester and relocalize PRRs to escape immunity.A better understanding of the cellular immune-surveillance machinery and viral immune evasion strategies may guide the development of antiviral therapeutics and vaccines.Supplementary information: The online version of this article (doi:10.1038/nrmicro.2016.45) contains supplementary material, which is available to authorized users. Twit Text FOAVip Viral evasion of intracellular DNA and RNA sensing ????Nat Rev Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=27174148 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27174148 #FOAvip English Wikipedia <ref>{{Cite pmid|27174148}}</ref> Viral evasion of intracellular DNA and RNA sensing #MMPMID27174148 Chan YK; Gack MU Nat Rev Microbiol 2016[]; 14 (6): 360-73 PMID27174148show ga Germline-encoded pattern recognition receptors (PRRs) mediate an early innate immune response against viral pathogens.Retinoic acid-inducible gene I protein (RIG-I) and melanoma differentiation-associated protein 5 (MDA5) are cytoplasmic sensors that detect viral RNA species and signal through the mitochondrial antiviral-signalling protein (MAVS) to induce the production of type I interferons (IFNs) and other cytokines.Intracellular DNA sensors, such as cyclic GMP?AMP synthase (cGAS) and IFN?-inducible protein 16 (IFI16), detect viral DNA in the cytoplasm and/or nucleus and signal through the stimulator of IFN genes (STING) to trigger an immune response.Viruses antagonize PRRs through the sequestration or modification of their viral genomes and through the manipulation of post-translational modifications of PRRs or their adaptor proteins. Some viruses cleave or degrade PRRs or their adaptors, or sequester and relocalize PRRs to escape immunity.A better understanding of the cellular immune-surveillance machinery and viral immune evasion strategies may guide the development of antiviral therapeutics and vaccines.Supplementary information: The online version of this article (doi:10.1038/nrmicro.2016.45) contains supplementary material, which is available to authorized users. äViral evasion of intracellular DNA and RNA sensing (epmc).pdf DeepDyve Pubget Overpricing