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10.1016/j.virol.2015.02.038 http://scihub22266oqcxt.onion/10.1016/j.virol.2015.02.038 C4424078!4424078 !25812764     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25812764 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Virology 2015 ; 479-480 (?): 609-18 Nephropedia Template TP {{tp|p=25812764 |t=2015. Viral activation of cellular metabolism |pdf=|usr=}}{{25812764 }} gab.com Text Viral activation of cellular metabolism JO: Virology http://www.kidney.de/pget.php?&tw=1&pmid=25812764 #FOAvip To ensure optimal environments for their replication and spread, viruses have evolved to alter many host cell pathways. In the last decade, metabolomic studies have shown that eukaryotic viruses induce large-scale alterations in host cellular metabolism. Most viruses examined to date induce aerobic glycolysis also known as the Warburg effect. Many viruses tested also induce fatty acid synthesis as well as glutaminolysis. These modifications of carbon source utilization by infected cells can increase available energy for virus replication and virion production, provide specific cellular substrates for virus particles and create viral replication niches while increasing infected cell survival. Each virus species also likely requires unique metabolic changes for successful spread and recent research has identified additional virus-specific metabolic changes induced by many virus species. A better understanding of the metabolic alterations required for the replication of each virus may lead to novel therapeutic approaches through targeted inhibition of specific cellular metabolic pathways. Twit Text FOAVip Viral activation of cellular metabolism ????Virology http://www.kidney.de/pget.php?&tw=1&pmid=25812764 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25812764 #FOAvip English Wikipedia <ref>{{Cite pmid|25812764 }}</ref> Viral activation of cellular metabolism #MMPMID25812764 Sanchez EL ; Lagunoff M Virology 2015[May]; 479-480 (?): 609-18 PMID25812764 show ga To ensure optimal environments for their replication and spread, viruses have evolved to alter many host cell pathways. In the last decade, metabolomic studies have shown that eukaryotic viruses induce large-scale alterations in host cellular metabolism. Most viruses examined to date induce aerobic glycolysis also known as the Warburg effect. Many viruses tested also induce fatty acid synthesis as well as glutaminolysis. These modifications of carbon source utilization by infected cells can increase available energy for virus replication and virion production, provide specific cellular substrates for virus particles and create viral replication niches while increasing infected cell survival. Each virus species also likely requires unique metabolic changes for successful spread and recent research has identified additional virus-specific metabolic changes induced by many virus species. A better understanding of the metabolic alterations required for the replication of each virus may lead to novel therapeutic approaches through targeted inhibition of specific cellular metabolic pathways. |*Host-Pathogen Interactions [MESH] |*Metabolism [MESH] |*Virus Physiological Phenomena [MESH] |*Virus Replication [MESH] |Cytosol/chemistry [MESH] |Energy Metabolism [MESH] |Eukaryota/*virology [MESH] |Fatty Acids/metabolism [MESH] |Glutamine/metabolism [MESH]Viral activation of cellular metabolism (epmc).pdf DeepDyve Pubget Overpricing