Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.kint.2017.09.021 http://scihub22266oqcxt.onion/10.1016/j.kint.2017.09.021 C5846847!5846847 !29241625     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29241625 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29241625 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Kidney+Int 2018 ; 93 (3 ): 643-655 Nephropedia Template TP {{tp|p=29241625 |t=2018. Vinculin is required to maintain glomerular barrier integrity |pdf=|usr=}}{{29241625 }} gab.com Text Vinculin is required to maintain glomerular barrier integrity JO: Kidney Int http://www.kidney.de/pget.php?&tw=1&pmid=29241625 #FOAvip Cell-matrix interactions and podocyte intercellular junctions are key for maintaining the glomerular filtration barrier. Vinculin, a cytoplasmic protein, couples actin filaments to integrin-mediated cell-matrix adhesions and to cadherin-based intercellular junctions. Here, we examined the role of vinculin in podocytes by the generation of a podocyte-specific knockout mouse. Mice lacking podocyte vinculin had increased albuminuria and foot process effacement following injury in vivo. Analysis of primary podocytes isolated from the mutant mice revealed defects in cell protrusions, altered focal adhesion size and signaling, as well as impaired cell migration. Furthermore, we found a marked mislocalization of the intercellular junction protein zonula occludens-1. In kidney sections from patients with focal segmental glomerulosclerosis, minimal change disease and membranous nephropathy, we observed dramatic differences in the expression levels and localization of vinculin. Thus, our results suggest that vinculin is necessary to maintain the integrity of the glomerular filtration barrier by modulating podocyte foot processes and stabilizing intercellular junctions. Twit Text FOAVip Vinculin is required to maintain glomerular barrier integrity ????Kidney Int http://www.kidney.de/pget.php?&tw=1&pmid=29241625 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29241625 #FOAvip English Wikipedia <ref>{{Cite pmid|29241625 }}</ref> Vinculin is required to maintain glomerular barrier integrity #MMPMID29241625 Lausecker F ; Tian X ; Inoue K ; Wang Z ; Pedigo CE ; Hassan H ; Liu C ; Zimmer M ; Jinno S ; Huckle AL ; Hamidi H ; Ross RS ; Zent R ; Ballestrem C ; Lennon R ; Ishibe S Kidney Int 2018[Mar]; 93 (3 ): 643-655 PMID29241625 show ga Cell-matrix interactions and podocyte intercellular junctions are key for maintaining the glomerular filtration barrier. Vinculin, a cytoplasmic protein, couples actin filaments to integrin-mediated cell-matrix adhesions and to cadherin-based intercellular junctions. Here, we examined the role of vinculin in podocytes by the generation of a podocyte-specific knockout mouse. Mice lacking podocyte vinculin had increased albuminuria and foot process effacement following injury in vivo. Analysis of primary podocytes isolated from the mutant mice revealed defects in cell protrusions, altered focal adhesion size and signaling, as well as impaired cell migration. Furthermore, we found a marked mislocalization of the intercellular junction protein zonula occludens-1. In kidney sections from patients with focal segmental glomerulosclerosis, minimal change disease and membranous nephropathy, we observed dramatic differences in the expression levels and localization of vinculin. Thus, our results suggest that vinculin is necessary to maintain the integrity of the glomerular filtration barrier by modulating podocyte foot processes and stabilizing intercellular junctions. |Albuminuria/genetics/metabolism [MESH] |Animals [MESH] |Cell Movement [MESH] |Cell Surface Extensions/metabolism/pathology [MESH] |Cells, Cultured [MESH] |Focal Adhesion Kinase 1/metabolism [MESH] |Focal Adhesions/metabolism/pathology [MESH] |Glomerulonephritis, Membranous/*metabolism/pathology [MESH] |Glomerulosclerosis, Focal Segmental/*metabolism/pathology [MESH] |Mechanotransduction, Cellular [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Nephrosis, Lipoid/*metabolism/pathology [MESH] |Phosphorylation [MESH] |Podocytes/*metabolism/pathology [MESH] |Vinculin/deficiency/genetics/*metabolism [MESH]Vinculin is required to maintain glomerular barrier integrity (epmc).pdf DeepDyve Pubget Overpricing