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10.1007/s00018-017-2511-3

http://scihub22266oqcxt.onion/10.1007/s00018-017-2511-3
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suck abstract from ncbi


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pmid28401269
      Cell+Mol+Life+Sci 2017 ; 74 (16 ): 2999-3009
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  • Vinculin in cell-cell and cell-matrix adhesions #MMPMID28401269
  • Bays JL ; DeMali KA
  • Cell Mol Life Sci 2017[Aug]; 74 (16 ): 2999-3009 PMID28401269 show ga
  • Vinculin was identified as a component of focal adhesions and adherens junctions nearly 40 years ago. Since that time, remarkable progress has been made in understanding its activation, regulation and function. Here we discuss the current understanding of the roles of vinculin in cell-cell and cell-matrix adhesions. Emphasis is placed on the how vinculin is recruited, activated and regulated. We also highlight the recent understanding of how vinculin responds to and transmits force at integrin- and cadherin-containing adhesion complexes to the cytoskeleton. Furthermore, we discuss roles of vinculin in binding to and rearranging the actin cytoskeleton.
  • |Actin Cytoskeleton/*metabolism [MESH]
  • |Adherens Junctions/*metabolism [MESH]
  • |Animals [MESH]
  • |Cadherins/*metabolism [MESH]
  • |Cell Adhesion [MESH]
  • |Cell Movement [MESH]
  • |Focal Adhesions/*metabolism [MESH]
  • |Humans [MESH]
  • |Integrins/*metabolism [MESH]
  • |Mechanotransduction, Cellular [MESH]
  • |Models, Molecular [MESH]
  • |Protein Interaction Maps [MESH]


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