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2017 ; 276
(1
): 178-191
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Viewing Siglecs through the lens of tumor immunology
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Fraschilla I
; Pillai S
Immunol Rev
2017[Mar]; 276
(1
): 178-191
PMID28258691
show ga
Many Siglecs function as inhibitory receptors on innate and adaptive immune cells
and may contribute to the attenuation of immune responses to tumors. Siglec 9 on
neutrophils and Siglec 7 on NK cells are prominent examples of inhibitory Siglecs
that can potentially dampen anti-tumor immunity. CD169 is a Siglec that may
function as an adhesion molecule and a facilitator of the recognition and
internalization of sialic acid decorated apoptotic bodies and exosomes derived
from tumors. It can potentially contribute to both the attenuation as well as the
facilitation of anti-tumor immunity. Siglecs have been best studied in the tumor
context in animal models of cancer. Modulators of Siglec function are likely to
be developed and investigated clinically in a cancer context over the next few
years.
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