Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25354044
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Curr+Opin+Endocrinol+Diabetes+Obes
2014 ; 21
(6
): 447-53
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Vibration therapy: clinical applications in bone
#MMPMID25354044
Thompson WR
; Yen SS
; Rubin J
Curr Opin Endocrinol Diabetes Obes
2014[Dec]; 21
(6
): 447-53
PMID25354044
show ga
PURPOSE OF REVIEW: The musculoskeletal system is largely regulated through
dynamic physical activity and is compromised by cessation of physical loading.
There is a need to recreate the anabolic effects of loading on the
musculoskeletal system, especially in frail individuals who cannot exercise.
Vibration therapy is designed to be a nonpharmacological analogue of physical
activity, with an intention to promote bone and muscle strength. RECENT FINDINGS:
Animal and human studies suggest that high-frequency, low-magnitude vibration
therapy improves bone strength by increasing bone formation and decreasing bone
resorption. There is also evidence that vibration therapy is useful in treating
sarcopenia, which confounds skeletal fragility and fall risk in aging.
Enhancement of skeletal and muscle strength involves regulating the
differentiation of mesenchymal stem cells to build these tissues; mesenchymal
stem cell lineage allocation is positively promoted by vibration signals.
SUMMARY: Vibration therapy may be useful as a primary treatment as well as an
adjunct to both physical and pharmacological treatments, but future studies must
pay close attention to compliance and dosing patterns, and importantly, the
vibration signal, be it low-intensity vibration (<1g) appropriate for treatment
of frail individuals or high-intensity vibration (>1g) marketed as a training
exercise.