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10.1172/JCI81130 http://scihub22266oqcxt.onion/10.1172/JCI81130 C4811151!4811151 !26974161     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26974161 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26974161 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Clin+Invest 2016 ; 126 (4 ): 1163-72 Nephropedia Template TP {{tp|p=26974161 |t=2016. Versatile roles of extracellular vesicles in cancer |pdf=|usr=}}{{26974161 }} gab.com Text Versatile roles of extracellular vesicles in cancer JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=26974161 #FOAvip Numerous studies have shown that non-cell-autonomous regulation of cancer cells is an important aspect of tumorigenesis. Cancer cells need to communicate with stromal cells by humoral factors such as VEGF, FGFs, and Wnt in order to survive. Recently, extracellular vesicles (EVs) have also been shown to be involved in cell-cell communication between cancer cells and the surrounding microenvironment and to be important for the development of cancer. In addition, these EVs contain small noncoding RNAs, including microRNAs (miRNAs), which contribute to the malignancy of cancer cells. Here, we provide an overview of current research on EVs, especially miRNAs in EVs. We also propose strategies to treat cancers by targeting EVs around cancer cells. Twit Text FOAVip Versatile roles of extracellular vesicles in cancer ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=26974161 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26974161 #FOAvip English Wikipedia <ref>{{Cite pmid|26974161 }}</ref> Versatile roles of extracellular vesicles in cancer #MMPMID26974161 Kosaka N ; Yoshioka Y ; Fujita Y ; Ochiya T J Clin Invest 2016[Apr]; 126 (4 ): 1163-72 PMID26974161 show ga Numerous studies have shown that non-cell-autonomous regulation of cancer cells is an important aspect of tumorigenesis. Cancer cells need to communicate with stromal cells by humoral factors such as VEGF, FGFs, and Wnt in order to survive. Recently, extracellular vesicles (EVs) have also been shown to be involved in cell-cell communication between cancer cells and the surrounding microenvironment and to be important for the development of cancer. In addition, these EVs contain small noncoding RNAs, including microRNAs (miRNAs), which contribute to the malignancy of cancer cells. Here, we provide an overview of current research on EVs, especially miRNAs in EVs. We also propose strategies to treat cancers by targeting EVs around cancer cells. |*Cell Communication [MESH] |*Tumor Microenvironment [MESH] |Animals [MESH] |Cell-Derived Microparticles/*metabolism/pathology [MESH] |Exosomes/*metabolism/pathology [MESH] |Humans [MESH] |MicroRNAs/metabolism [MESH] |Neoplasms/*metabolism/pathology/therapy [MESH]Versatile roles of extracellular vesicles in cancer (epmc).pdf DeepDyve Pubget Overpricing