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10.1038/nchembio.2337 http://scihub22266oqcxt.onion/10.1038/nchembio.2337 C5773344!5773344 !28328921     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28328921 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Chem+Biol 2017 ; 13 (4 ): 350-359 Nephropedia Template TP {{tp|p=28328921 |t=2017. Versatile modes of cellular regulation via cyclic dinucleotides |pdf=|usr=}}{{28328921 }} gab.com Text Versatile modes of cellular regulation via cyclic dinucleotides JO: Nat Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=28328921 #FOAvip Since the discovery of c-di-GMP almost three decades ago, cyclic dinucleotides (CDNs) have emerged as widely used signaling molecules in most kingdoms of life. The family of second messengers now includes c-di-AMP and distinct versions of mixed cyclic GMP-AMP (cGAMP) compounds. In addition to these nucleotides, a vast number of proteins for the production and turnover of these molecules have been described, as well as effectors that translate the signals into physiological responses. The latter include, but are not limited to, mechanisms for adaptation and survival in prokaryotes, persistence and virulence of bacterial pathogens, and immune responses to viral and bacterial invasion in eukaryotes. In this review, we will focus on recent discoveries and emerging themes that illustrate the ubiquity and versatility of cyclic dinucleotide function at the transcriptional and post-translational levels and, in particular, on insights gained through mechanistic structure-function analyses. Twit Text FOAVip Versatile modes of cellular regulation via cyclic dinucleotides ????Nat Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=28328921 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28328921 #FOAvip English Wikipedia <ref>{{Cite pmid|28328921 }}</ref> Versatile modes of cellular regulation via cyclic dinucleotides #MMPMID28328921 Krasteva PV ; Sondermann H Nat Chem Biol 2017[Mar]; 13 (4 ): 350-359 PMID28328921 show ga Since the discovery of c-di-GMP almost three decades ago, cyclic dinucleotides (CDNs) have emerged as widely used signaling molecules in most kingdoms of life. The family of second messengers now includes c-di-AMP and distinct versions of mixed cyclic GMP-AMP (cGAMP) compounds. In addition to these nucleotides, a vast number of proteins for the production and turnover of these molecules have been described, as well as effectors that translate the signals into physiological responses. The latter include, but are not limited to, mechanisms for adaptation and survival in prokaryotes, persistence and virulence of bacterial pathogens, and immune responses to viral and bacterial invasion in eukaryotes. In this review, we will focus on recent discoveries and emerging themes that illustrate the ubiquity and versatility of cyclic dinucleotide function at the transcriptional and post-translational levels and, in particular, on insights gained through mechanistic structure-function analyses. |Amino Acid Sequence [MESH] |Animals [MESH] |Bacteria/metabolism [MESH] |Eukaryota/*metabolism [MESH] |Humans [MESH] |Models, Molecular [MESH] |Nucleotides, Cyclic/chemistry/*metabolism [MESH] |Prokaryotic Cells/*metabolism [MESH]Versatile modes of cellular regulation via cyclic dinucleotides (epmc).pdf DeepDyve Pubget Overpricing