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Versatile microRNA biogenesis in animals and their viruses
#MMPMID24823351
Xie M
; Steitz JA
RNA Biol
2014[]; 11
(6
): 673-81
PMID24823351
show ga
MicroRNAs (miRNAs) are ubiquitous gene regulators that modulate essential
cellular processes at the post-transcriptional level. In metazoans and their
viruses, most miRNAs are produced from hairpin-containing primary transcripts
that are sequentially cleaved by nuclear Drosha and cytoplasmic Dicer. In the
last decade, alternative mechanisms that bypass either the Drosha or Dicer
cleavage step have emerged, increasing the complexity of the miRNA regulatory
network. Here, we highlight non-canonical pathways that generate miRNAs using a
variety of molecular machineries that play fundamental roles in the biogenesis
and processing of other classes of cellular RNAs.