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Vergence eye movements in patients with schizophrenia
#MMPMID25088242
Bolding MS
; Lahti AC
; White D
; Moore C
; Gurler D
; Gawne TJ
; Gamlin PD
Vision Res
2014[Sep]; 102
(?): 64-70
PMID25088242
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Previous studies have shown that smooth pursuit eye movements are impaired in
patients with schizophrenia. However, under normal viewing conditions, targets
move not only in the frontoparallel plane but also in depth, and tracking them
requires both smooth pursuit and vergence eye movements. Although previous
studies in humans and non-human primates suggest that these two eye movement
subsystems are relatively independent of one another, to our knowledge, there
have been no prior studies of vergence tracking behavior in patients with
schizophrenia. Therefore, we have investigated these eye movements in patients
with schizophrenia and in healthy controls. We found that patients with
schizophrenia exhibited substantially lower gains compared to healthy controls
during vergence tracking at all tested speeds (e.g. 0.25 Hz vergence tracking
mean gain of 0.59 vs. 0.86). Further, consistent with previous reports, patients
with schizophrenia exhibited significantly lower gains than healthy controls
during smooth pursuit at higher target speeds (e.g. 0.5 Hz smooth pursuit mean
gain of 0.64 vs. 0.73). In addition, there was a modest (r?0.5), but significant,
correlation between smooth pursuit and vergence tracking performance in patients
with schizophrenia. Our observations clearly demonstrate substantial vergence
tracking deficits in patients with schizophrenia. In these patients, deficits for
smooth pursuit and vergence tracking are partially correlated suggesting overlap
in the central control of smooth pursuit and vergence eye movements.
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