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2017 ; 63
(ä): 165-170
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Vascular patterning in human heterotopic ossification
#MMPMID28315426
Cocks M
; Mohan A
; Meyers CA
; Ding C
; Levi B
; McCarthy E
; James AW
Hum Pathol
2017[May]; 63
(ä): 165-170
PMID28315426
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Heterotopic ossification (HO, also termed myositis ossificans) is the formation
of extra-skeletal bone in muscle and soft tissues. HO is a tissue repair process
gone awry, and is a common complication of surgery and traumatic injury. Medical
strategies to prevent and treat HO fall well short of addressing the clinical
need. Better characterization of the tissues supporting HO is critical to
identifying therapies directed against this common and sometimes devastating
condition. The physiologic processes of osteogenesis and angiogenesis are highly
coupled and interdependent. However, few efforts have been made to document the
vascular patterning within heterotopic ossification. Here, surgical pathology
case files of 29 human HO specimens were examined by vascular histomorphometric
analysis. Results demonstrate a temporospatial patterning of HO vascularity that
depends on the "maturity" of the bony lesion. In sum, human HO demonstrates a
time- and space-dependent pattern of vascularization suggesting a coupled
pathophysiologic process involving the coordinate processes of osteogenesis and
angiogenesis. Further imaging studies may be used to further characterize
vasculogenesis within HO and whether anti-angiogenic therapies are a conceivable
future therapy for this common condition.
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