Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25415615
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Curr+Opin+Nephrol+Hypertens
2015 ; 24
(1
): 8-13
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Vascular effects of dietary salt
#MMPMID25415615
Edwards DG
; Farquhar WB
Curr Opin Nephrol Hypertens
2015[Jan]; 24
(1
): 8-13
PMID25415615
show ga
PURPOSE OF REVIEW: High dietary salt intake is detrimental in hypertensive and
salt-sensitive individuals; however, there are a large number of normotensive
salt-resistant individuals for whom dietary salt may also be harmful as a result
of the blood pressure-independent effects of salt. This review will focus on the
growing evidence that salt has adverse effects on the vasculature, independent of
blood pressure. RECENT FINDINGS: Data from both animal and human studies provide
evidence that salt impairs endothelial function and increases arterial stiffness,
independent of blood pressure. High dietary salt results in oxidative stress and
increased endothelial cell stiffness, which impair endothelial function, whereas
transforming growth factor beta promotes increased arterial stiffness in the
presence of endothelial dysfunction. SUMMARY: Health policies and most clinical
research are focused on the adverse effects of dietary salt on blood pressure;
however, there is an increasing body of evidence to support a deleterious effect
of dietary salt on endothelial function and arterial stiffness independent of
blood pressure. Endothelial dysfunction and increased arterial stiffness are
predictors of cardiovascular disease; therefore, reducing excess dietary salt
should be considered important for overall vascular health in addition to blood
pressure.
free
free
free
