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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Br+J+Pharmacol
2017 ; 174
(10
): 1002-1014
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Vascular actions of relaxin: nitric oxide and beyond
#MMPMID27590257
Leo CH
; Jelinic M
; Ng HH
; Marshall SA
; Novak J
; Tare M
; Conrad KP
; Parry LJ
Br J Pharmacol
2017[May]; 174
(10
): 1002-1014
PMID27590257
show ga
The peptide hormone relaxin regulates the essential maternal haemodynamic
adaptations in early pregnancy through direct actions on the renal and systemic
vasculature. These vascular actions of relaxin occur mainly through
endothelium-derived NO-mediated vasodilator pathways and improvements in arterial
compliance in small resistance-size arteries. This work catalysed a plethora of
studies which revealed quite heterogeneous responses across the different regions
of the vasculature, and also uncovered NO-independent mechanisms of relaxin
action. In this review, we first describe the role of endogenous relaxin in
maintaining normal vascular function, largely referring to work in pregnant and
male relaxin-deficient animals. We then discuss the diversity of mechanisms
mediating relaxin action in different vascular beds, including the involvement of
prostanoids, VEGF, endothelium-derived hyperpolarisation and antioxidant activity
in addition to the classic NO-mediated vasodilatory pathway. We conclude the
review with current perspectives on the vascular remodelling capabilities of
relaxin. LINKED ARTICLES: This article is part of a themed section on Recent
Progress in the Understanding of Relaxin Family Peptides and their Receptors. To
view the other articles in this section visit
http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.10/issuetoc.
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