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10.3390/ijms160511574 http://scihub22266oqcxt.onion/10.3390/ijms160511574 C4463718!4463718 !26006236     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26006236 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26006236 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Sci 2015 ; 16 (5 ): 11574-608 Nephropedia Template TP {{tp|p=26006236 |t=2015. Vasa vasorum in atherosclerosis and clinical significance |pdf=|usr=}}{{26006236 }} gab.com Text Vasa vasorum in atherosclerosis and clinical significance JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26006236 #FOAvip Atherosclerosis is a chronic inflammatory disease that leads to several acute cardiovascular complications with poor prognosis. For decades, the role of the adventitial vasa vasorum (VV) in the initiation and progression of atherosclerosis has received broad attention. The presence of VV neovascularization precedes the apparent symptoms of clinical atherosclerosis. VV also mediates inflammatory cell infiltration, intimal thickening, intraplaque hemorrhage, and subsequent atherothrombosis that results in stroke or myocardial infarction. Intraplaque neovessels originating from VV can be immature and hence susceptible to leakage, and are thus regarded as the leading cause of intraplaque hemorrhage. Evidence supports VV as a new surrogate target of atherosclerosis evaluation and treatment. This review provides an overview into the relationship between VV and atherosclerosis, including the anatomy and function of VV, the stimuli of VV neovascularization, and the available underlying mechanisms that lead to poor prognosis. We also summarize translational researches on VV imaging modalities and potential therapies that target VV neovascularization or its stimuli. Twit Text FOAVip Vasa vasorum in atherosclerosis and clinical significance ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26006236 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26006236 #FOAvip English Wikipedia <ref>{{Cite pmid|26006236 }}</ref> Vasa vasorum in atherosclerosis and clinical significance #MMPMID26006236 Xu J ; Lu X ; Shi GP Int J Mol Sci 2015[May]; 16 (5 ): 11574-608 PMID26006236 show ga Atherosclerosis is a chronic inflammatory disease that leads to several acute cardiovascular complications with poor prognosis. For decades, the role of the adventitial vasa vasorum (VV) in the initiation and progression of atherosclerosis has received broad attention. The presence of VV neovascularization precedes the apparent symptoms of clinical atherosclerosis. VV also mediates inflammatory cell infiltration, intimal thickening, intraplaque hemorrhage, and subsequent atherothrombosis that results in stroke or myocardial infarction. Intraplaque neovessels originating from VV can be immature and hence susceptible to leakage, and are thus regarded as the leading cause of intraplaque hemorrhage. Evidence supports VV as a new surrogate target of atherosclerosis evaluation and treatment. This review provides an overview into the relationship between VV and atherosclerosis, including the anatomy and function of VV, the stimuli of VV neovascularization, and the available underlying mechanisms that lead to poor prognosis. We also summarize translational researches on VV imaging modalities and potential therapies that target VV neovascularization or its stimuli. |Angiogenesis Inhibitors/therapeutic use [MESH] |Animals [MESH] |Atherosclerosis/diagnosis/*pathology [MESH] |Humans [MESH] |Neovascularization, Pathologic/diagnosis/drug therapy/*pathology [MESH] |Prognosis [MESH]Vasa vasorum in atherosclerosis and clinical significance (epmc).pdf DeepDyve Pubget Overpricing