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10.1016/j.jmb.2016.01.022 http://scihub22266oqcxt.onion/10.1016/j.jmb.2016.01.022 C4860093!4860093 !26827725     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26827725 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       J+Mol+Biol 2016 ; 428 (9 Pt B ): 1927-46 Nephropedia Template TP {{tp|p=26827725 |t=2016. Various Themes of Myosin Regulation |pdf=|usr=}}{{26827725 }} gab.com Text Various Themes of Myosin Regulation JO: J Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=26827725 #FOAvip Members of the myosin superfamily are actin-based molecular motors that are indispensable for cellular homeostasis. The vast functional and structural diversity of myosins accounts for the variety and complexity of the underlying allosteric regulatory mechanisms that determine the activation or inhibition of myosin motor activity and enable precise timing and spatial aspects of myosin function at the cellular level. This review focuses on the molecular basis of posttranslational regulation of eukaryotic myosins from different classes across species by allosteric intrinsic and extrinsic effectors. First, we highlight the impact of heavy and light chain phosphorylation. Second, we outline intramolecular regulatory mechanisms such as autoinhibition and subsequent activation. Third, we discuss diverse extramolecular allosteric mechanisms ranging from actin-linked regulatory mechanisms to myosin:cargo interactions. At last, we briefly outline the allosteric regulation of myosins with synthetic compounds. Twit Text FOAVip Various Themes of Myosin Regulation ????J Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=26827725 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26827725 #FOAvip English Wikipedia <ref>{{Cite pmid|26827725 }}</ref> Various Themes of Myosin Regulation #MMPMID26827725 Heissler SM ; Sellers JR J Mol Biol 2016[May]; 428 (9 Pt B ): 1927-46 PMID26827725 show ga Members of the myosin superfamily are actin-based molecular motors that are indispensable for cellular homeostasis. The vast functional and structural diversity of myosins accounts for the variety and complexity of the underlying allosteric regulatory mechanisms that determine the activation or inhibition of myosin motor activity and enable precise timing and spatial aspects of myosin function at the cellular level. This review focuses on the molecular basis of posttranslational regulation of eukaryotic myosins from different classes across species by allosteric intrinsic and extrinsic effectors. First, we highlight the impact of heavy and light chain phosphorylation. Second, we outline intramolecular regulatory mechanisms such as autoinhibition and subsequent activation. Third, we discuss diverse extramolecular allosteric mechanisms ranging from actin-linked regulatory mechanisms to myosin:cargo interactions. At last, we briefly outline the allosteric regulation of myosins with synthetic compounds. |Allosteric Regulation [MESH] |Molecular Motor Proteins/*chemistry/*metabolism [MESH] |Myosins/*chemistry/*metabolism [MESH] |Phosphorylation [MESH]Various Themes of Myosin Regulation (epmc).pdf DeepDyve Pubget Overpricing