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2015 ; 2015
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Varicocele
#MMPMID26168774
Macleod R
; Biyani CS
; Cartledge J
; Eardley I
BMJ Clin Evid
2015[Jul]; 2015
(ä): ä PMID26168774
show ga
INTRODUCTION: Varicocele is estimated to affect about 15% of the general male
population. It usually occurs only on the left side, and is often asymptomatic.
There is little evidence that varicocele reduces male fertility, although it is
found in 12% of male partners of couples presenting with infertility and in 25%
of men with abnormal semen analysis. METHODS AND OUTCOMES: We conducted a
systematic overview, aiming to answer the following clinical question: What are
the effects of treatments in adult males with varicocele? We searched: Medline,
Embase, The Cochrane Library, and other important databases up to November 2013
(Clinical Evidence overviews are updated periodically; please check our website
for the most up-to-date version of this overview). RESULTS: Searching of
electronic databases retrieved 203 studies. After deduplication and removal of
conference abstracts, 91 records were screened for inclusion in the overview.
Appraisal of titles and abstracts led to the exclusion of 53 studies and the
further review of 38 full publications. Of the 38 full articles evaluated, one
existing systematic review was updated and two systematic reviews and five RCTs
were added at this update. We performed a GRADE evaluation of nine PICO
combinations. CONCLUSIONS: In this systematic overview we categorised the
efficacy for four interventions, based on information relating to the
effectiveness of embolisation, expectant management, sclerotherapy, and surgical
ligation.