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10.4161/hv.28626 http://scihub22266oqcxt.onion/10.4161/hv.28626 C5396253!5396253 !24718366     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24718366 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24718366 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Hum+Vaccin+Immunother 2014 ; 10 (6 ): 1449-56 Nephropedia Template TP {{tp|p=24718366 |t=2014. Vaccine against norovirus |pdf=|usr=}}{{24718366 }} gab.com Text Vaccine against norovirus JO: Hum Vaccin Immunother http://www.kidney.de/pget.php?&tw=1&pmid=24718366 #FOAvip Noroviruses (NoVs) are important pathogens causing epidemic acute gastroenteritis affecting millions of people worldwide. Due to the inability to cultivate NoVs, current NoV vaccine development relies on bioengineering technologies to produce virus-like particles (VLPs) and other subviral particles of NoVs as subunit vaccines. The first VLP vaccine has reached phase II clinical trials and several others are under development in pre-clinical research. Several subviral complexes made from the protruding (P) domains of NoV capsid share common features of easy production, high stability and high immunogenicity and thus are candidates for low cost vaccines. These P domain complexes can also be used as vaccine platforms to present foreign antigens for potential dual vaccines against NoVs and other pathogens. Development of NoV vaccines also faces other challenges, including genetic diversity of NoVs, limit understanding of NoV immunology and evolution, and lack of an efficient NoV animal model for vaccine assessment, which are discussed in this article. Twit Text FOAVip Vaccine against norovirus ????Hum Vaccin Immunother http://www.kidney.de/pget.php?&tw=1&pmid=24718366 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24718366 #FOAvip English Wikipedia <ref>{{Cite pmid|24718366 }}</ref> Vaccine against norovirus #MMPMID24718366 Tan M ; Jiang X Hum Vaccin Immunother 2014[]; 10 (6 ): 1449-56 PMID24718366 show ga Noroviruses (NoVs) are important pathogens causing epidemic acute gastroenteritis affecting millions of people worldwide. Due to the inability to cultivate NoVs, current NoV vaccine development relies on bioengineering technologies to produce virus-like particles (VLPs) and other subviral particles of NoVs as subunit vaccines. The first VLP vaccine has reached phase II clinical trials and several others are under development in pre-clinical research. Several subviral complexes made from the protruding (P) domains of NoV capsid share common features of easy production, high stability and high immunogenicity and thus are candidates for low cost vaccines. These P domain complexes can also be used as vaccine platforms to present foreign antigens for potential dual vaccines against NoVs and other pathogens. Development of NoV vaccines also faces other challenges, including genetic diversity of NoVs, limit understanding of NoV immunology and evolution, and lack of an efficient NoV animal model for vaccine assessment, which are discussed in this article. |Caliciviridae Infections/*epidemiology/*prevention & control [MESH] |Clinical Trials, Phase II as Topic [MESH] |Drug Discovery/*trends [MESH] |Gastroenteritis/epidemiology/prevention & control [MESH] |Genetic Variation [MESH] |Humans [MESH] |Norovirus/classification/genetics/*immunology [MESH] |Vaccines, Synthetic/immunology/isolation & purification [MESH]Vaccine against norovirus (epmc).pdf DeepDyve Pubget Overpricing