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2014 ; 2
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V(D)J Recombination: Mechanism, Errors, and Fidelity
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Microbiol Spectr
2014[Dec]; 2
(6
): ä PMID26104458
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V(D)J recombination, the mechanism responsible for generating antigen receptor
diversity, has the potential to generate aberrant DNA rearrangements in
developing lymphocytes. Indeed, the recombinase has been implicated in several
different kinds of errors leading to oncogenic transformation. Here we review the
basic aspects of V(D)J recombination, mechanisms underlying aberrant DNA
rearrangements, and the types of aberrant events uncovered in recent genomewide
analyses of lymphoid neoplasms.