Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29449659
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Nat+Rev+Cancer
2018 ; 18
(5
): 313-322
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Using immunotherapy to boost the abscopal effect
#MMPMID29449659
Ngwa W
; Irabor OC
; Schoenfeld JD
; Hesser J
; Demaria S
; Formenti SC
Nat Rev Cancer
2018[May]; 18
(5
): 313-322
PMID29449659
show ga
More than 60 years ago, the effect whereby radiotherapy at one site may lead to
regression of metastatic cancer at distant sites that are not irradiated was
described and called the abscopal effect (from 'ab scopus', that is, away from
the target). The abscopal effect has been connected to mechanisms involving the
immune system. However, the effect is rare because at the time of treatment,
established immune-tolerance mechanisms may hamper the development of
sufficiently robust abscopal responses. Today, the growing consensus is that
combining radiotherapy with immunotherapy provides an opportunity to boost
abscopal response rates, extending the use of radiotherapy to treatment of both
local and metastatic disease. In this Opinion article, we review evidence for
this growing consensus and highlight emerging limitations to boosting the
abscopal effect using immunotherapy. This is followed by a perspective on current
and potential cross-disciplinary approaches, including the use of smart materials
to address these limitations.
free
free
free
